Journal of Pathology and Translational Medicine

Case Study

Nodular Fasciitis of the Parotid Gland, Masquerading as Pleomorphic Adenoma: Chung Su Hwang, Chang Hun Lee, Ahrong Kim, Nari Shin, Won Young Park, Min Gyoung Park, Do Youn Park; Korean J Pathol. 2014;48(5):366-370. Published online October 27, 2014; DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.5.366

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It is difficult to distinguish nodular fasciitis (NF) from other neoplasm of the parotid gland, especially pleomorphic adenoma (PA) by fine needle aspiration cytology. A 39-year-old female noticed a mass in the parotid region. The aspirate material showed cohesive parts composed of the cells that had oval or spindle-shaped nuclei and relatively abundant cytoplasm and some cells with plasmacytoid features. The background substance was fibromyxoid. PA was diagnosed based on the cytologic findings. Subsequently, parotidectomy was performed and NF was diagnosed based on histologic and immunohistochemical findings. NF in the parotid region is rare and may be misdiagnosed as other benign or malignant tumors of the parotid gland. The clinical history of rapid growth and the presence of mitoses and inflammatory cells help to distinguish NF from PA. In addition, immunohistochemical stains for smooth muscle actin and CD68 are useful to confirm the diagnosis of NF.

Citations

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A case report of nodular fasciitis of the parotid gland: An entity of concern
Andrea Varazzani, Laura Tognin, Silvia Eleonora Gazzani, Luigi Corcione, Tito Poli
Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology.2024; 36(3): 422. CrossRef
A Rare Case of Parotid Nodular Fasciitis in a Six-Month-Old Female
Mazin Merdad, Linah Qasim, Mohammed Nujoom, Hani Z Marzouki, Abdulaziz Neazy
Cureus.2023;[Epub] CrossRef
A Rare Case of Nodular Fasciitis Presenting as a Parotid Tumor: Clues to Cytodiagnosis
Seetu Palo, Chitrawati Bal Gargade
Journal of Laboratory Physicians.2023;[Epub] CrossRef
Condylar Reshape in Orthognathic Surgery: Morphovolumetric and Densitometric Analysis Based on 3D Imaging and Digital Workflow
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Journal of Maxillofacial and Oral Surgery.2022; 21(2): 501. CrossRef
Nodular fasciitis of the submandibular gland
Ting Suen Wong, Richard Wei Chern Gan, Laszlo Karsai, Bun Yin Winson Wong
BMJ Case Reports.2022; 15(4): e245584. CrossRef
Nodular fasciitis in cervicofacial region: a rare case description and literature review
Vincenzo Abbate, Giovanni Dell’Aversana Orabona, Giovanni Audino, Antonio Romano, Paola Bonavolontà, Daniela Russo, Silvia Varricchio, Roberto Ferrigno, Giorgio Iaconetta, Luigi Califano
Oral Surgery.2022; 15(4): 550. CrossRef
Nodular fasciitis of the parotid gland engulfing the facial nerve: a conservative approach
Stephen Bennett, Kristian Hutson, Olakunle Ajayi, Andreas Hilger
BMJ Case Reports.2019; 12(10): e231203. CrossRef

Brief Case Report

Mediastinal Thymolipoma with Striated Myoid Cells: Report of a Peculiar Case: Young Keum Kim, Nari Shin, Won Young Park, Do Youn Park, Gi Young Huh, Chang Hun Lee; Korean J Pathol. 2013;47(6):596-598. Published online December 24, 2013; DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.6.596

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Thymoangiolipoma: A rare histologic variant of thymolipoma in a patient with myasthenia gravis
Mohammad Hossein Anbardar, Fatemeh Amirmoezi, Armin Amirian
Rare Tumors.2020; 12: 203636132097921. CrossRef
Thymic epithelial neoplasms with rhabdomyomatous component: a clinicopathological and immunohistochemical study of 7 cases
Neda Kalhor, Cesar A. Moran
Human Pathology.2019; 83: 100. CrossRef

Case Report

Ectomesenchymal Chondromyxoid Tumor in the Anterior Tongue: Case Report of a Unique Tumor: Min Gyoung Pak, Kyung Bin Kim, Nari Shin, Woo Kyung Kim, Dong Hoon Shin, Kyung Un Choi, Mee Young Sol; Korean J Pathol. 2012;46(2):192-196. Published online April 25, 2012; DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.2.192

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Abstract PDF

Ectomesenchymal chondromyxoid tumor (ECMT) is a rare tumor, exclusively arising in the anterior tongue. Thirty-eight cases have been reported in the English literature. It usually presents as a sessile protrusion and shows round to spindle cells embedded in myxoid to chondroid stroma. Tumor cells are almost always positive for polyclonal glial fibrillary acidic protein (GFAP). We report our experience in the recent treatment of a case of ECMT, the third case in 3 years. The mass in the anterior tongue revealed characteristic morphologic features of ECMT and the expression of polyclonal GFAP. Although ECMT should be differentiated from other mesenchymal tumors including myoepithelioma, its clinical, morphological, and immunohistochemical features enable its diagnosis, especially when pathologists are aware of it.

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Chondroid choristoma of the tongue: A rare case report
Sumaiya Nezam, Roquaiya Nishat, ShababAhmed Khan, JeevendraNath Shukla
National Journal of Maxillofacial Surgery.2022; 13(4): 121. CrossRef
Ectomesenchymal chondromyxoid tumor: a comprehensive updated review of the literature and case report
Astrid Truschnegg, Stephan Acham, Lumnije Kqiku, Norbert Jakse, Alfred Beham
International Journal of Oral Science.2018;[Epub] CrossRef
Clinical features of ectomesenchymal chondromyxoid tumors: A systematic review of the literature
Masanari G. Kato, Evren Erkul, Kendall S. Brewer, Emily E. Harruff, Shaun A. Nguyen, Terry A. Day
Oral Oncology.2017; 67: 192. CrossRef
Cyclin D1 Expression in Ectomesenchymal Chondromyxoid Tumor of the Anterior Tongue
Jan Laco, Radovan Mottl, Walter Höbling, Stephan Ihrler, Petr Grossmann, Alena Skalova, Ales Ryska
International Journal of Surgical Pathology.2016; 24(7): 586. CrossRef
Nodular lesion in the buccal mucosa
Bruna Jalfim Maraschin, Ana Carolina Amorim Pellicioli, Lélia Batista de Souza, Pantelis Varvaki Rados, Marco Antonio Trevizani Martins, Manoela Domingues Martins
The Journal of the American Dental Association.2015; 146(3): 196. CrossRef

Original Article

Molecular Biological Characteristics of Differentiated Early Gastric Cancer on the Basis of Mucin Expression.: Nari Shin, Hye Yeon Kim, Woo Kyung Kim, Min Gyung Park, Kyung Bin Kim, Dong Hoon Shin, Kyung Un Choi, Jee Yeon Kim, Chang Hun Lee, Gi Young Huh, Mee Young Sol, Do Youn Park; Korean J Pathol. 2011;45(1):69-78.; DOI: https://doi.org/10.4132/KoreanJPathol.2011.45.1.69

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Abstract PDF

BACKGROUND
It is clear that the biologic characteristics of gastric cancer are different on the basis of mucin phenotypes. However, there are unabated controversies on the exact biologic differences of mucin expression in gastric cancer.
METHODS
We analyzed various protein expressions and microsatellite instability (MSI) status based on mucin expression in 130 differentiated early gastric adenocarcinoma cases. Furthermore, we evaluated the genomic alternation in 10 selected differentiated early gastric adenocarcinoma cases using array based comparative genomic hybridization (aCGH).
RESULTS
Intestinal mucin predominant subtype showed significantly elevated p53 protein and caudal-related homeobox 2 expression, and delocalization of beta catenin expressions compared to the gastric mucin predominant subtype. On MSI status, the gastric mucin predominant subtype more frequently showed unstable status than the intestinal mucin predominant subtype. CGH study showed more frequent chromosomal gain and loss in the intestinal mucin predominant subtype than the gastric mucin predominant subtype, albeit without statistical significance. Interestingly, there were significant differences in chromosomal alternation between four mucin phenotypes.
CONCLUSIONS
Study results suggest possible different points of biologic behaviors in early differentiated gastric adenocarcinomas by mucin expression type.

Citations

Citations to this article as recorded by

Mucin Expression in Gastric Cancer: Reappraisal of Its Clinicopathologic and Prognostic Significance
Dae Hwan Kim, Nari Shin, Gwang Ha Kim, Geum Am Song, Tae-Yong Jeon, Dong-Heon Kim, Gregory Y. Lauwers, Do Youn Park
Archives of Pathology & Laboratory Medicine.2013; 137(8): 1047. CrossRef
Microsatellite Instability Status in Gastric Cancer: A Reappraisal of Its Clinical Significance and Relationship with Mucin Phenotypes
Joo-Yeun Kim, Na Ri Shin, Ahrong Kim, Hyun-Jeong Lee, Won-young Park, Jee-Yeon Kim, Chang-Hun Lee, Gi-Young Huh, Do Youn Park
Korean Journal of Pathology.2013; 47(1): 28. CrossRef

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